label-free imaging of immune cells in the living retina
In collaboration with the Schallek Lab at the University of Rochester we discovered it is possible to image resident and infiltrating immune cells in the mouse retina using adaptive optics and scattered infrared light alone.
This discovery may allow us to better examine immune responses in ocular inflammation.
Indocyanine green dye labelling of immune cells
With colleagues at UCL and the University of Bristol we have previously investigated the ability of a safe angiographic dye to be used to label immune cells in the eye.
Progress towards this and its potential has been demonstrated in mouse models and in early human work that we have published.
If successful it could allow imaging of immune cells in the deep retina and choroid allowing many types of Uveitis to be assessed.
The main advantage is that this could be used to better diagnose and monitor disease, for example determining if immunosuppressive drugs are working faster, or when a patient's disease has gone into remission.
We are continuing to work in this space to bring the application to clinic in collaboration with a wider team.
