Immune Responses to AAV gene therapy vectors
Cloaking AAV immune responses to improve the effectiveness of gene therapy
In collaboration with Dr Ying Kai Chan and Dr George Church at Harvard University, we investigated how modulation of the TLR9 pathway can delay and in some cases prevent immune responses to the vectors. This can lead to more effective production of the desired proteins and a reduced immune cell infiltration. There is increasing recognition of immune responses to AAV vectors and applying new imaging methods may allow us to better understand their application.